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Each antibiotic targets a speci c cellular function (such as inhibiting peptidoglycan biosynthesis or altering membrane sterols to increase cell permeability). In the face of selective pressure for survival, bacteria have responded with adaptations that resist antibiotics in eight different ways (Table 8.12; Davies, 1994). Key mechanisms of antibiotic resistance include: ef ux pumps that reduce the intracellular concentration of the antibiotic, enzymes that inactive the antibiotic, and alteration of the structure of the cellular site targeted by the antibiotic (Table 8.12). The eight mechanisms of antibiotic resistance are phenotypes. The way to thwart the development of such phenotypes is to understand their

= '-

+ pi+1p. (8.2)

11-3.1.1 Flow Computation. As was remarked in Section 11-1.2, CFD is now quite well established as a tool for modeling mixing processes in singlephase systems, although the currently popular Reynolds-averaging models using the k turbulence model are not appropriate for the local turbulence conditions

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Many of the applications you develop in Flash will consist of some ActionScript. The complexity of the ActionScript will be determined based on what the application will be. In this example you will be using an external class to develop the video player. The first part of the application to be developed is the ActionScript code, which is broken up in classes for greater scalability. The main ActionScript will be attached to the application using the Document class. To start, look at the class skeleton, which will give you a better idea of how the application will flow.

Let K = ( x z - l , z z )C R be an arbitrary interval. It is easy to calculate the coefficients c1, c2 E R of an affine map z~ : K , K,

8. The next field selects the Video mode. You can choose whether you prefer sharper images or smoother motion. Your choice here is determined by the content of your podcast. For most podcasts, Normal mode should be just fine. 9. Be sure to check the 2-pass video encoding. This makes your render take twice as long, but provides much higher video quality. 10. Select your resolution from the Frame size drop-down menu, or choose Custom and enter a custom frame size in the Width and Height fields. 11. Leave Field order and Pixel aspect fields alone, and click Audiences to get to the next screen of settings, as shown in Figure 13.23.

If you had previously installed InDesign, you get the Uninstall Options screen. It has several options for what is uninstalled:

Equivalence of the elements ( K t ,Pk, gk)and ( K ,P k , E&) At this point it remains to be shown that the general NCdClec elements are equivalent under transformation (7.1 12), (7.1 13): E = @ K ( E ) ,

If you want songs to sound good on your iPod or iPhone, turn off the Sound Check feature to prevent the player from robbing the songs of dynamic range by normalizing the sound. Here s how to turn off Sound Check on the various models of iPod and on the iPhone: Sixth-generation iPod or iPod nano. Choose Main menu Settings Sound Check, and then press the Select button to switch between On and Off. iPod shuffle. Connect the iPod shuffle to your Mac, then click it in the Devices category in the Source list to display its control screens. On the Settings tab, clear the Enable Sound Check check box, and then click Apply. iPod touch. Press Home, touch Settings, touch Music, and then touch the Sound Check slider to move it to the On position or the Off position. iPhone. Press Home, touch Settings, touch iPod, and then touch the Sound Check slider to move it to the On position or the Off position.

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For an example of how to use the Distribute command, see Creating multiple copies of fields later in this chapter.